[DC Chemicals] QS-21

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[DC Chemicals] QS-21

 

Description:

면역 자극 saponin QS-21은 강력한 백신 보조제로 사용될 수 있습니다. QS-21은 항원 제시 세포(APC)와 T 세포에 작용하여 Th2 체액성 및 Th1 세포 매개 면역 반응을 자극합니다. QS-21은 카스파제-1 의존성 사이토카인, IL-1β 및 IL-18의 후속 방출과 함께 NLRP3 인플라마좀을 활성화할 수 있습니다.

In Vivo:

Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively

Field of application:

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18
 

Chemicals Properties
Cas No.:	141256-04-4
Chemical Name:	QS-21
Formula:	C92H148O46
M.Wt:	1990.13195514679
Purity:	>98%, Standard References Grade
Sotrage:	4°C for 1 year, -20°C for more than 2 years

 

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